Alu Elements Support Independent Origin of Prosimian, Platyrrhine, and Catarrhine Mhc-DRB Genes
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چکیده
منابع مشابه
Alu elements support independent origin of prosimian, platyrrhine, and catarrhine Mhc-DRB genes.
The primate major histocompatibility complex (Mhc) genes fall into two classes and each of the classes into several families. Of the class II families, the DRB family has a long and complex evolutionary history marked by gene turnover, rearrangement, and molecular convergence. Because the history is not easily decipherable from sequences alone, Alu element insertions were used as cladistic mark...
متن کاملTHE ORIGIN AND STRUCTURE OF Alu ELEMENTS
Highly repetitive DNA sequences account for more than 50% of the human genome. The L1 and Alu families harbor the most common mammalian long and short interspersed elements. An Alu element is a dimer of similar, but not identical, fragments of total size about 300 bp, and originates from the 7SL RNA gene. Each element contains a bipartite promoter for RNA polymerase III, a poly(A) tract located...
متن کاملAlu insertion loci and platyrrhine primate phylogeny.
Short INterspersed Elements (SINEs) make very useful phylogenetic markers because the integration of a particular element at a location in the genome is irreversible and of known polarity. These attributes make analysis of SINEs as phylogenetic characters an essentially homoplasy-free affair. Alu elements are primate-specific SINEs that make up a large portion of the human genome and are also w...
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The DRB family of human class II major histocompatibility complex (Mhc) loci is unusual in that individuals differ in the number and combination of genes (haplotypes) they carry. Indications are that both the allelic and haplotype polymorphisms of the DRB loci predate speciation. Searching for the evolutionary origins of these polymorphisms, we have sequenced five DRB clones isolated from a cDN...
متن کاملAlu Elements and Human Disease
The Alu element Methylation of Alu Repeats DNA Demethylation Mechanism of Retrotransposition Alu elements and Disease Conclusion and Outlook Endnotes
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ژورنال
عنوان ژورنال: Genome Research
سال: 2000
ISSN: 1088-9051
DOI: 10.1101/gr.10.5.634